1261563-79-4Relevant academic research and scientific papers
N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors
Bruncko, Milan,Tahir, Stephen K.,Song, Xiaohong,Chen, Jun,Ding, Hong,Huth, Jeffrey R.,Jin, Sha,Judge, Russell A.,Madar, David J.,Park, Chang H.,Park, Cheol-Min,Petros, Andrew M.,Tse, Christin,Rosenberg, Saul H.,Elmore, Steven W.
, p. 7503 - 7506 (2011/02/16)
We describe the development of a novel series of N-aryl-benzimidazolone HSP90 inhibitors (9) targeting the N-terminal ATP-ase site. SAR development was influenced by structure-based design based around X-ray structures of ligand bound HSP90 complexes. Lea
