1261869-76-4

Usage

Uses

Used in Pharmaceutical Research:
1-oxoisoindoline-5-carbonitrile is used as a potential drug candidate for its structure and biological activities, including its anticonvulsant and anti-inflammatory properties. It is being studied for its potential to treat various conditions that may benefit from these effects.
Used in Organic Synthesis:
1-oxoisoindoline-5-carbonitrile is used as a building block and intermediate in the synthesis of other organic compounds. Its unique structure allows it to be a valuable component in creating a variety of chemical products.
Used in Materials Science:
As a component in the development of new materials, 1-oxoisoindoline-5-carbonitrile is utilized for its potential to contribute to the properties of advanced materials, possibly enhancing their performance in various applications.
Used in Drug Development:
1-oxoisoindoline-5-carbonitrile is explored for its potential role in drug development, capitalizing on its biological activities and chemical properties to create new therapeutic agents for treating diseases and conditions that require novel treatment options.

InChI:InChI=1S/C9H6N2O/c10-4-6-1-2-8-7(3-6)5-11-9(8)12/h1-3H,5H2,(H,11,12)

Upstream product

• 557-21-1 zinc(II) cyanide 
• 552330-86-6 5-bromoisoindolin-1-one 
• 78471-43-9 methyl 4-bromo-2-(bromomethyl)benzoate 
• 1440519-96-9 2-(4-methoxy-benzyl)-1-oxo-2,3-dihydro-1H-isoindole-5-carbonitrile 
• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 165111-46-6 2-bromomethyl-4-cyano-benzoic acid methyl ester 
• 103261-67-2 4-cyano-2-methylbenzoic acid methyl ester 
• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 

Downstream Products

• 23386-40-5 1-oxo-2,3-dihydro-1H-isoindole-5-carboxylic acid 

Relevant academic research and scientific papers

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of the catalytic subunit of the PRC2 enhancer of zeste homologue 2 (EZH2) being recently approved fo

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists to reduce elevated aldosterone levels, which are associated with deleterious effects on various organ systems including the heart, vasculature, kidney, and central nervous system (CNS). A benzamide pyridine hit derived from a focused screen was successfully developed into a series of potent and selective 3-pyridyl isoindolin-1-ones CYP11B2 inhibitors. Our systematic structure-activity relationship study enabled us to identify unique structural features that result in high selectivity against the closely homologous cortisol synthase (CYP11B1). We evaluated advanced lead molecules, exemplified by compound 52, in an in vivo cynomolgus monkey acute adrenocorticotropic hormone (ACTH) challenge model and demonstrated a superior 100-fold in vivo selectivity against CYP11B1.

Degradable hydrogel under physiological conditions

The present invention discloses a hydrogel that can be degraded under physiological conditions. The hydrogel includes at least one backbone moiety and an optional crosslinking moiety, and biodegradable linkers connecting backbone moieties and crosslinking moieties can be degraded by intramolecular cyclization.

CHROMAN DERIVATIVES AS TRPM8 INHIBITORS

Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.