23386-40-5

Basic information

• Product Name: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-
• Synonyms: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-;1-oxoisoindoline-5-carboxylic acid;1-oxo-2,3-dihydro-1H-isoindole-5-carboxylic acid;2,3-dihydro-1-oxo-1H-Isoindole-5-carboxylic acid
• CAS NO: 23386-40-5
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.15678
• Mol File: 23386-40-5.mol

Chemical Properties

• Boiling Point: 558.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.79±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-(23386-40-5)
• EPA Substance Registry System: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-(23386-40-5)

Safety Data

• Hazardous Substances Data: 23386-40-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxois utilized as a key intermediate in the synthesis of various pharmaceuticals due to its ability to form diverse chemical structures and its compatibility with a range of biological targets. Its presence in the molecular framework of drugs can contribute to their therapeutic efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxoserves as a fundamental building block for creating a variety of complex organic molecules. Its reactivity and structural features facilitate the construction of novel compounds with potential applications in various chemical and material sciences.
Used in Medicinal Chemistry:
1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxois employed as a precursor in medicinal chemistry for the preparation of biologically active molecules. Its incorporation into drug candidates can enhance their pharmacological properties, such as potency, selectivity, and bioavailability, making it an essential component in the development of innovative therapeutic agents.

Upstream product

• 1261869-76-4 1-oxoisoindoline-5-carbonitrile 
• 165111-46-6 2-bromomethyl-4-cyano-benzoic acid methyl ester 
• 103261-67-2 4-cyano-2-methylbenzoic acid methyl ester 
• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 
• 926307-72-4 methyl 1-oxo-2,3-dihydro-1H-isoindole-5-carboxylate 
• 552330-86-6 5-bromoisoindolin-1-one 

Downstream Products

• 1421922-95-3 5-acetyl-2,3-dihydro-1H-isoindol-1-one 

Relevant articles and documents

CHROMAN DERIVATIVES AS TRPM8 INHIBITORS

Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

AMIDINE COMPOUND OR SALT THEREOF

The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida, the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent. A compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof is useful as an anti-fungal agent.

TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have a structure where the definitions of the variables are provided herein.