23386-40-5

Basic information

• Product Name: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-
• Synonyms: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-;1-oxoisoindoline-5-carboxylic acid;1-oxo-2,3-dihydro-1H-isoindole-5-carboxylic acid;2,3-dihydro-1-oxo-1H-Isoindole-5-carboxylic acid
• CAS NO: 23386-40-5
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.15678
• Mol File: 23386-40-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 558.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.79±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-(23386-40-5)
• EPA Substance Registry System: 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo-(23386-40-5)

Safety Data

• Hazardous Substances Data: 23386-40-5(Hazardous Substances Data)

Usage

General Description

1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo- is a chemical compound with the molecular formula C10H7NO3. It is a heterocyclic aromatic compound containing a six-membered ring with nitrogen and carboxylic acid functional groups. 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-1-oxo- is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceuticals and biologically active molecules. Its structural and functional properties make it a valuable precursor in the development of drugs and other biologically relevant compounds.

Upstream product

• 1261869-76-4 1-oxoisoindoline-5-carbonitrile 
• 165111-46-6 2-bromomethyl-4-cyano-benzoic acid methyl ester 
• 103261-67-2 4-cyano-2-methylbenzoic acid methyl ester 
• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 
• 926307-72-4 methyl 1-oxo-2,3-dihydro-1H-isoindole-5-carboxylate 
• 552330-86-6 5-bromoisoindolin-1-one 

Downstream Products

• 1421922-95-3 5-acetyl-2,3-dihydro-1H-isoindol-1-one 

Relevant articles and documents

CHROMAN DERIVATIVES AS TRPM8 INHIBITORS

Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have a structure where the definitions of the variables are provided herein.