1261994-22-2Relevant academic research and scientific papers
Synthesis of multi-substituted dihydrofurans via palladium-catalysed coupling between 2,3-alkadienols and pronucleophiles
Tsukamoto, Hirokazu,Ito, Kazuya,Doi, Takayuki
supporting information, p. 5102 - 5105 (2018/05/26)
Multi-substituted dihydrofurans were obtained from a palladium-catalysed coupling reaction between 2,3-alkadienols and ketones bearing an electron-withdrawing group at the α-position. Methanol as a solvent was essential for the initial dehydrative substitution to suppress the competitive hydroalkylation of the diene moiety. The substitution would be followed by intramolecular hydroalkoxylation under the same catalysis.
One-pot construction of aza-or oxa-bridged benzocycloheptanes from readily available 2,3-allenyl malonates or 2,3-allenols and o-iodobenzaldehyde or imine
Li, Qiankun,Jiang, Xinpeng,Fu, Chunling,Ma, Shengming
supporting information; experimental part, p. 466 - 469 (2011/04/15)
A Pd(OAc)2-catalyzed reaction of 2,3-alkadienyl malonates or 2,3-allenols with o-iodobenzaldehyde or its N-tosyl imine occurred smoothly in MeCN at 80 °C to form the oxa-or aza-bridged benzocycloheptane derivatives with important biological pot
