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Usage

Uses

Used in Organic Synthesis:
Benzene, 1-(phenylmethyl)-4-[(trimethylsilyl)oxy]is used as a reagent in organic synthesis for introducing the trimethylsilyloxy group onto other molecules. The trimethylsilyloxy group serves as a versatile protecting group for alcohols and other functional groups during chemical reactions, allowing for selective reactions to occur without affecting the protected groups.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzene, 1-(phenylmethyl)-4-[(trimethylsilyl)oxy]is utilized in the development of new drugs. Its unique structure and reactivity enable the synthesis of novel drug candidates with potential therapeutic applications. Benzene, 1-(phenylmethyl)-4-[(trimethylsilyl)oxy]-'s ability to act as a protecting group also aids in the synthesis of complex organic molecules with multiple functional groups.
Used in Chemical Industry:
Benzene, 1-(phenylmethyl)-4-[(trimethylsilyl)oxy]finds applications in the chemical industry for the synthesis of various organic compounds. Its versatility as a reagent and protecting group allows for the development of new chemical entities with potential applications in various fields, such as materials science, agrochemicals, and specialty chemicals.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 101-53-1 p-benzylphenol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 216017-01-5 4-benzyl-4′-methyl-1,1′-biphenyl 
• 101-53-1 p-benzylphenol 

Relevant academic research and scientific papers

Preparation, characterization and use of 1,3-disulfonic acid imidazolium hydrogen sulfate as an efficient, halogen-free and reusable ionic liquid catalyst for the trimethylsilyl protection of hydroxyl groups and deprotection of the obtained trimethylsilanes

Novel 1,3-disulfonic acid imidazolium hydrogen sulfate, a halogen-free ionic liquid, is a recyclable and eco-benign catalyst for the trimethylsilyl protection of hydroxyl groups at room temperature under solvent free conditions to afford trimethylsilanes in excellent yields (92-100%) and in very short reaction times (1-5 min). Deprotection of the resulting trimethylsilanes can also be achieved using the same catalyst in methanol. The catalyst was characterized by IR, 1H NMR, 13C NMR and MS studies. All the products were extensively characterized by IR, 1H NMR, MS, and elemental and melting point analyses. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst can be recovered and reused for several times without loss of activity. The work-up of the reaction consists of a simple separation, followed by concentration of the crude product and purification.

Cross-coupling of aryl/alkenyl ethers with aryl grignard reagents through nickel-catalyzed C-O activation

The formation of a C-C bond has been achieved through the cleavage of the sp2 C-O bond of aryl/alkenyl ethers catalyzed by a nickel complex, and by using Grignard reagents as nucleophiles (see scheme). This method displays a broad substrate scope and leads to good to excellent yields of the aryl-aryl or alkenyl-aryl cross-coupling products.

Succinimide-N-sulfonic acid: A mild, efficient, and reusable catalyst for the chemoselective trimethylsilylation of alcohols and phenols

Succinimide-N-sulfonic acid (SuSA) is easily prepared by the reaction of succinimide with chlorosulfonic acid. This reagent is able to efficiently catalyze the chemoselective trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS). All reactions were performed under mild reaction conditions, giving excellent yields. Copyright Taylor & Francis Group, LLC.

Chemoselective and catalytic trimethylsilylation of alcohols and phenols by 1,1,1,3,3,3-hexamethyldisilazane and catalytic amounts of PhMe 3N+Br3-

An efficient procedure for the trimethylsilylation of alcohols and phenols is presented. The combination of 1,1,1,3,3,3-hexamethyldisilazane and a catalytic amount of phenyltrimethylammonium tribromide (PhMe3N +Br3-) was found to be effective for the trimethylsilylation of alcohols and phenols. The protection reaction is very simple and homogenously performed in dichloromethane at room temperature and mild conditions.