1262235-14-2

Upstream product

• 663176-91-8 [(4R,5S)-5-allyl-2,2-dimethyl-1,3-dioxolan-4-yl]methyl pivalate 
• 116773-95-6 (R)-4-<(tert-butyldimethylsilyl)oxy>-1-pentene 
• 64584-92-5 (R)-pent-4-en-2-ol 
• 1262235-09-5 tert-butyldimethyl-[(E,1R)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-enoxy]silane 
• 1262235-06-2 C₁₃H₂₂O₅ 
• 1262235-13-1 2-(trimethylsilyl)ethyl 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate 
• 1262235-05-1 (R,Z)-5-bromopent-4-en-2-ol 
• 1262235-04-0 2-((E)-3-((4S,5R)-2,2-dimethyl-5-(pivaloyloxymethyl)-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoic acid 
• 603039-01-6 ((4R,5S)-5-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl pivalate 
• 603039-00-5 ((4R,5S)-5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl pivalate 

Downstream Products

• 1262235-15-3 (S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5R)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate 
• 1262235-03-9 (S,Z)-5-bromopent-4-en-2-yl 2-((E)-3-((4S,5S)-5-formyl-2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-enyl)-4,6-dimethoxybenzoate 

Relevant academic research and scientific papers

Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction

A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6'-C7' bond.