1262297-41-5

Upstream product

• 119822-24-1 dimethyl (4-aminobenzyl)malonate 
• 17641-30-4 4-chlorosulfonyl-cinnamic acid 
• 621-82-9 Cinnamic acid 
• 38323-22-7 dimethyl (4-nitrobenzylidene)malonate 
• 108-59-8 malonic acid dimethyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 124090-10-4 dimethyl (4-nitrobenzyl)propanedioate 

Downstream Products

• 1262297-42-6 C₂₁H₂₂N₂O₈S 
• 1262297-34-6 malBel 

Relevant academic research and scientific papers

METAL COMPLEXES HAVING DUAL HISTONE DEACETYLASE INHIBITORY AND DNA-BINDING ACTIVITY

Compounds comprising a metal complex having the structure [X-Y-Z-Mn+]p+. B are disclosed in which X is a histone deacetylase inhibitor, Mn+ is a DNA -binding heavy metal ion, Y is an aliphatic or aromatic spacer or is absent, and Z is a mono- or bi-dentate or chelating donor linker, or a bridging linker, P+ designates the charge on the complex ion, which may be positive, negative or absent and B is a counterion or is absent. The linker Z is labile and its metal complex X-Y-Z-Mn+ is capable of being hydrolysed in-vivo. The compounds find application in the treatment of cancer.