14025-83-3

Basic information

• Product Name: Benzenepropanoic acid, b-cyano-, ethyl ester
• Synonyms: 3-cyano-3-phenyl-propionic acid ethyl ester;(+/-)-3-phenyl-3-cyano-propionic acid ethyl ester;Ethyl 3-cyano-3-phenylpropionate;Ethyl-β-phenyl-β-cyanopropionate;Ethyl β-cyano-β-phenylpropionate
• CAS NO: 14025-83-3
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241
• Mol File: 14025-83-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-cyano-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-cyano-, ethyl ester(14025-83-3)
• EPA Substance Registry System: Benzenepropanoic acid, b-cyano-, ethyl ester(14025-83-3)

Safety Data

• Hazardous Substances Data: 14025-83-3(Hazardous Substances Data)

Upstream product

• 506-77-4 cyanogen chloride 
• 7677-24-9 trimethylsilyl cyanide 
• 5292-53-5 diethyl benzalmalonate 
• 151-50-8 potassium cyanide 
• 607-81-8 diethyl 2-benzylmalonate 
• 100-52-7 benzaldehyde 
• 140-29-4 phenylacetonitrile 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 635-51-8 2-phenylsuccinic acid 
• 64504-82-1 ethyl 3-cyano-3-phenyl-2-propenoate 
• 41175-39-7 4-hydroxy-2-phenyl-butanenitrile 
• 1575-47-9 4-phenyl-5H-furan-2-one 
• 91060-28-5 phenylsuccinic hydrazide 
• 40877-30-3 3-cyano-3-phenyl-pentanedioic acid diethyl ester 
• 29427-69-8 3-oxoindan-1-carboxylic acid 
• 41175-40-0 4-amino-3-phenylbutan-1-ol 
• 147410-43-3 tert-butyl 3-phenylpyrrolidine-1-carboxylate 
• 1171518-22-1 benzyl 3-phenylpyrrolidine-1-carboxylate 
• 1262786-37-7 N-(4,4-difluorocyclohexyl)-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide 
• 1262786-36-6 N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide 
• 1262786-32-2 2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide 
• 1262786-30-0 4-[({4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}amino)sulfonyl]benzamide 

Relevant articles and documents

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A novel approach for enantioselective cyanation of cyclopropanols and their derivatives through copper-catalyzed radical relay processes has been developed. Various cyclopropanols and cyclopropanone acetals are compatible to the catalytic conditions, providing β-carbonyl nitriles with excellent enantioselectivity. These products can be readily converted to chiral γ-amino acids derivatives and drugs such as (R)-baclofen. Preliminary mechanistic studies have supported a ring-opening process for cyclopropanoxy radicals followed by copper-catalyzed enantioselective cyanation of benzylic radicals to form the C?CN bonds in an enantioselective manner. (Figure presented.).

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