1262879-51-5

Basic information

• Product Name: tert-butyl [5-methoxy-2-(2-oxo-2-phenylethyl)phenyl]carbamate
• Synonyms: tert-butyl [5-methoxy-2-(2-oxo-2-phenylethyl)phenyl]carbamate
• CAS NO: 1262879-51-5
• Molecular Weight: 341.407
• Mol File: 1262879-51-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl [5-methoxy-2-(2-oxo-2-phenylethyl)phenyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [5-methoxy-2-(2-oxo-2-phenylethyl)phenyl]carbamate(1262879-51-5)
• EPA Substance Registry System: tert-butyl [5-methoxy-2-(2-oxo-2-phenylethyl)phenyl]carbamate(1262879-51-5)

Safety Data

• Hazardous Substances Data: 1262879-51-5(Hazardous Substances Data)

Upstream product

• 187731-65-3 (2-amino-4-methoxyphenyl)methanol 
• 4294-95-5 4-methoxyanthranilic acid 
• 100-52-7 benzaldehyde 
• 50868-72-9 5-methoxy-o-toluidine 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 138343-79-0 (5-methoxy-2-methyl-phenyl)-carbamic acid t-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1262879-72-0 methyl 6-[2-(2-tert-butoxycarbonylamino-4-methoxyphenyl)-3-oxo-3-phenylpropyl]pyridine-2-carboxylate 
• 57826-36-5 6-methoxy-2-phenyl-1H-indole 
• 1262875-83-1 6-(6-methoxy-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylic acid 
• 1262875-28-4 methyl 6-(6-methoxy-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylate 
• 1262875-34-2 methyl 3-(6-methoxy-2-phenyl-1H-indol-3-ylmethyl)benzoate 

Relevant articles and documents

INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

PROBLEM TO BE SOLVED: To provide a compound having EP1 receptor antagonism, a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same and a medical use thereof. SOLUTION: There is provided a compound having EP1 receptor antagonism and represented by the general formula (I), where A is a pyridine ring or the like, Y1 is a C1-6 alkylene group or the like, Y2 is a single bond or the like, R1 is a hydrogen atom or the like, R2 is a C3-6 cycloalkylene group with a ring substituted by a C1-6 alkyl group or the like, R3 is a carboxyl group or the like, R4 is a hydrogen atom, R5 is a hydrogen atom or the like, R6 is a C1-6 alkyl group or the like and R7 represents a hydrogen atom or the like, or a pharmaceutically acceptable salt thereof. The compound (I) can further used as a therapeutic agent or prophylactic agent for various symptoms of LUTS, especially OABs. COPYRIGHT: (C)2015,JPOandINPIT

INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.