1262983-75-4

Upstream product

• 85-44-9 phthalic anhydride 
• 175547-82-7 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbohydrazide 
• 5181-35-1 2-bromoethoxyphthalimide 
• 1262983-70-9 2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide 
• 524-38-9 N-hydroxyphthalimide 
• 35929-79-4 4-(4-chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Synthesis of some 1-{2-(phthalimido-N-oxy)-ethyl} derivatives of 4-(4-substituted phenyl)-2,6-dimethyl-1,4-dihydro-3,5-bis-N-4-oxo-2- phenylquinazolin-3(4H)-ylcarboxamides

A series of 1-{2-(phthalimido-N-oxy)-ethyl}-4-(4-substituted phenyl)-2,6-dimelhyl-1,4-dihydro-3,5-bis-N-(4-oxo-2-phenylquinazolin-3(4H) -ylcarboxamides (6a-d) have been synthesized via a multistep reaction sequence. Ethyl acetoacetate, various araldehydes and aminonia were condensed in ethanol to yield diethyl 4-(4-substituted phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5- dicarboxylate (2a-d). Ester group of these 2a-d was replaced by hydrazine hydrate in dioxane to give 4-(4-substituted phenyl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarbohydrazide (3a-d). These were further treated with benzoxazine-4(3H)-one to give 4-(4-substituted phenyl)-2,6-dimethyl-1,4-dihydro- 3,5-bis-N-(4-oxo-2-phenylquinazolin-3(4H)-ylcarboxamides (4a-d). Final compounds 6a-d were obtained by refluxing 4a-d with bromoethoxyphthalimide (5). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR and mass spectral data.