1262984-77-9Relevant academic research and scientific papers
A kinetically controlled direct aldol addition of α-chloro thioesters via soft enolization
Alfie, Rachel J.,Truong, Ngoc,Yost, Julianne M.,Coltart, Don M.
, p. 185 - 189 (2017)
Herein we report that simple α-chloro thioesters undergo soft enolization and direct aldol addition to aldehydes in the presence of MgBr2·OEt2and i-Pr2NEt. At ?78?°C the reaction proceeds in a kinetically controlled manner
Direct carbon-carbon bond formation via soft enolization: Aldol addition of α-halogenated thioesters
Yost, Julianne M.,Alfie, Rachel J.,Tarsis, Emily M.,Chong, Insun,Coltart, Don M.
supporting information; experimental part, p. 571 - 572 (2011/02/26)
α-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr2·OEt 2 and i-Pr2NEt to produce α-halo-β-hydroxy thioesters.
