126312-59-2Relevant academic research and scientific papers
A convenient asymmetric synthesis of the unnatural amino acid 2,6-dimethyl-L-tyrosine
Dygos,Yonan,Scaros,Goodmonson,Getman,Periana,Beck
, p. 741 - 743 (2007/10/02)
The title compound was prepared in high optical purity by a five-step synthesis from 3,5-dimethylphenol on a kilogram scale. The key steps were a modified palladium-catalyzed coupling of an aryl iodide with methyl 2-acetamidoacrylate and hydrogenation of the resulting sterically hindered dehydroamino acid 4 using [Rh(1,5-COD)(R,R-DIPAMP)]BF4 as catalyst.
Process for producing 2,6-disubstituted tyrosine
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, (2008/06/13)
A process for making 2,6-disubstituted tyrosine by the noble metal coupling of a disubstituted aromatic halide or diazonium salt with an amino-protected 2-aminoacrylic acid to form a (Z)-β-(disubstituted phenyl)-α-acylaminoacrylate, and asymmetrically hydrogenating the acrylate to produce the 2,6-disubstituted tyrosine.
