875051-80-2

Basic information

• Product Name: 6-amino-5-bromo-N-methylpicolinamide
• Synonyms: 6-amino-5-bromo-N-methylpicolinamide
• CAS NO: 875051-80-2
• Molecular Formula: C7H8BrN3O
• Molecular Weight: 230.07
• Mol File: 875051-80-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-amino-5-bromo-N-methylpicolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-bromo-N-methylpicolinamide(875051-80-2)
• EPA Substance Registry System: 6-amino-5-bromo-N-methylpicolinamide(875051-80-2)

Safety Data

• Hazardous Substances Data: 875051-80-2(Hazardous Substances Data)

Upstream product

• 875051-78-8 N-(3-bromo-6-methylpyridin-2-yl)acetamide 
• 875051-81-3 C₈H₆BrN₂O₃^(1-)*K⁽¹⁺⁾ 
• 126325-46-0 2-amino-3-bromo-6-methyl-pyridine 
• 29682-15-3 methyl 5-bromopicolinate 
• 1616667-62-9 C₇H₆BrFN₂O 
• 1214336-44-3 methyl 5-bromo-6-fluoropyridine-2-carboxylate 
• 74-89-5 methylamine 
• 178876-82-9 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemical matter that is efficacious in preclinical models of neuropathic and inflammatory pain. (Chemical Presented).

Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution

We report the late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen. By this process, a series of functional groups and substituents bound to the ring through nitrogen, oxygen, sulfur, or carbon are installed. This functionalization is accomplished by a combination of fluorination and nucleophilic aromatic substitution of the installed fluoride. A diverse array of functionalities can be installed because of the mild reaction conditions revealed for nucleophilic aromatic substitutions (SNAr) of the 2-fluoroheteroarenes. An evaluation of the rates for substitution versus the rates for competitive processes provides a framework for planning this functionalization sequence. This process is illustrated by the modification of a series of medicinally important compounds, as well as the increase in efficiency of synthesis of several existing pharmaceuticals.

PYRIDINE DERIVATIVES

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.