126327-66-0Relevant academic research and scientific papers
Efficient preparation of polyfunctional organometallics via directed ortho -metalation
Wunderlich, Stefan H.,Bresser, Tomke,Dunst, Cora,Monzon, Gabriel,Knochel, Paul
experimental part, p. 2670 - 2678 (2010/09/05)
Highly functionalized organometallics are efficiently prepared in larger quantities (up to 4 g) by directed ortho-metalation using the previously reported amide bases TMP2Mn2MgCl24LiCl (TMP=2,2,6,6-tetramethylpiperidyl), TMP2Fe2MgCl24LiCl and TMP3La3MgCl25LiCl. The resulting organometallics undergo various reactions with electrophiles like acid chlorides, alkyl iodides, or aldehydes and provide the corresponding products in good to excellent yields. Georg Thieme Verlag Stuttgart New York.
First study of syntheses and reactivity of Grignard compounds in the diazine series. Diazines. Part 27
Leprêtre,Turck,Plé,Knochel,Quéguiner
, p. 265 - 273 (2007/10/03)
A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0°C or even room temperature.
Syntheses in the nitrogen π-deficient heterocycles series using a barbier type reaction under sonication. Diazines. Part 29
Leprêtre, Anne,Turck, Alain,Plé, Nelly,Quéguiner, Guy
, p. 3709 - 3715 (2007/10/03)
Barbier type reaction with lithium metal has been tested under sonication on pyridines, a cinnoline and on various diazines. This very convenient method allows a very fast and smooth functionalization of these heterocycles. (C) 2000 Elsevier Science Ltd.
