1263274-67-4

Basic information

• Product Name: 5-Chloro-2-fluoro-4-methylbenzoic acid
• Synonyms: 5-Chloro-2-fluoro-4-methylbenzoic acid;Benzoic acid, 5-chloro-2-fluoro-4-methyl-
• CAS NO: 1263274-67-4
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.5834432
• Mol File: 1263274-67-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Chloro-2-fluoro-4-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-fluoro-4-methylbenzoic acid(1263274-67-4)
• EPA Substance Registry System: 5-Chloro-2-fluoro-4-methylbenzoic acid(1263274-67-4)

Safety Data

• Hazardous Substances Data: 1263274-67-4(Hazardous Substances Data)

Usage

Uses

5-Chloro-2-fluoro-4-methylbenzoic Acid (cas# 1263274-67-4) is a useful reagent for the preparation of oxodihydropyridazine derivative as NaV inhibitor, which is useful for treating pain-related diseases.

Upstream product

• 7697-23-6 2-fluoro-4-methylbenzoic Acid 
• 124-38-9 carbon dioxide 
• 33406-96-1 2-chloro-5-fluorotoluene 
• 452-71-1 4-fluor-2-methylaniline 
• 93765-83-4 1-bromo-5-chloro-2-fluoro-4-methyl-benzene 
• 1355070-62-0 methyl 5-chloro-2-fluoro-4-methylbenzoate 

Downstream Products

• 1354962-97-2 5-chloro-2-fluoro-4-methyl-N-(methylsulfonyl)benzamide 
• 1354962-96-1 4-(bromomethyl)-5-chloro-2-fluoro-N-(methylsulfonyl)benzamide 
• 1443431-27-3 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid 
• 1443432-84-5 tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate 
• 1443432-77-6 tert-butyl 5-chloro-4-(bromomethyl)-2-fluorobenzoate 
• 1443431-31-9 5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt 
• 1443431-33-1 N-(azetidin-1-ylsulfonyl)-5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-2-fluorobenzamide 
• 1443431-35-3 5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N-[(3,3-difluoroazetidin-1-yl)sulfonyl]-2-fluorobenzamide 
• 1443432-75-4 tert-butyl 5-chloro-2-fluoro-4-methylbenzoate 

Relevant articles and documents

SODIUM ION CHANNEL INHIBITORS AND PHARMACEUTICALLY ACCEPTABLE SALTS AND POLYMORPHS THEREOF AND USES THEREOF

The present disclosure discloses sodium ion channel inhibitors, pharmaceutically acceptable salts and polymorphs thereof, and uses thereof. Specifically, the present disclosure discloses a polymorph of a compound of formula (X) and a preparation method th

N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF

The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.