1263379-47-0

Basic information

• Product Name: 5-(3-chlorophenyl)-4-(2,5-difluorophenyl)-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• Synonyms: 5-(3-chlorophenyl)-4-(2,5-difluorophenyl)-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• CAS NO: 1263379-47-0
• Molecular Weight: 406.887
• Mol File: 1263379-47-0.mol

Chemical Properties

• CAS DataBase Reference: 5-(3-chlorophenyl)-4-(2,5-difluorophenyl)-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-chlorophenyl)-4-(2,5-difluorophenyl)-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(1263379-47-0)
• EPA Substance Registry System: 5-(3-chlorophenyl)-4-(2,5-difluorophenyl)-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(1263379-47-0)

Safety Data

• Hazardous Substances Data: 1263379-47-0(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 50-00-0 formaldehyd 
• 1263379-36-7 5-(3-chlorophenyl)-4-(2,5-difluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety

A fast and efficient synthesis of some 1,4-disubstituted thiosemicarbazide derivatives is described. The reaction of 3-chlorobenzoic acid hydrazide with various aryl isothiocyanates gave thiosemicarbazide derivatives (1-11) in good yield. The cyclization of compounds (1-11) in the presence of 2% NaOH resulted in the formation of compounds (12-22) containing the 1,2,4-triazole ring. A series of new Mannich bases (23-33) related to the structure of 1,2,4-triazole has been also synthesized. All of these compounds were tested for their in vitro antibacterial activity against the reference strains of aerobic bacteria - 6 Gram-positive and 3 Gram-negative ones; 12 Staphylococcus aureus clinical isolates were also examined. An attempt was made to clarify the influence of the nature/position of substituents on antibacterial activity of compounds described.