126348-45-6

Upstream product

• 77853-01-1 (4-nitro-phenyl)-m-tolyl sulfone 
• 76590-34-6 (4-nitro-phenyl)-m-tolyl sulfide 
• 100-00-5 4-chlorobenzonitrile 
• 586-78-7 para-nitrophenyl bromide 
• 591-17-3 meta-bromotoluene 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 37924-22-4 4-(3-Methylphenylsulfonyl)-trifluormethansulfonanilid 

Relevant academic research and scientific papers

Palladium-catalyzed three-component diaryl sulfone synthesis exploiting the sulfur dioxide surrogate DABSO

SO(2) efficient: A three-component palladium-catalyzed coupling of aryl lithium compounds; sulfur dioxide (provided by the easy-to-handle solid surrogate, DABSO); and aryl, heteroaryl, and alkenyl (pseudo)halides yields a diverse library of sulfones. An electron-poor XantPhos-type ligand suppresses aryl-aryl exchange and is key to obtaining high yields.

Therapeutic amides

Amides having formula I: STR1 wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.