126354-82-3Relevant academic research and scientific papers
STUDIES ON STEREOSPECIFIC FORMATION OF P-CHIRAL INTERNUCLEOTIDE LINKAGE. SYNTHESIS OF (Rp,Rp)- AND (Sp,Sp)-THYMIDYLYL(3',5')THYMIDYLYL(3',5')THYMIDINE DI(O,O-PHOSPHOROTHIOATE) USING 2-NITROBENZYL GROUP AS A NEW S-PROTECTION
Lesnikowski, Z.J.,Jaworska, M.M.
, p. 3821 - 3824 (1989)
(Rp,Rp)- and (Sp,Sp)-diastereomers of thymidylyl(3',5')thymidylyl(3',5')thymidine di (O,O-phosphorothioate (6) were prepared in the stereospecific reaction of (Rp)- or (Sp)-isomer of 5'-O-monomethoxytritylthymidine 3'-O- (2) with 5'-OH activated 3'-O-acetylthymidine and subsequently with 5'-OH deprotected, 5'-OH activated derivative of resulted dinucleotide 3.
