STUDIES ON STEREOSPECIFIC FORMATION OF P-CHIRAL INTERNUCLEOTIDE LINKAGE. SYNTHESIS OF (Rp,Rp)- AND (Sp,Sp)-THYMIDYLYL(3',5')THYMIDYLYL(3',5')THYMIDINE DI(O,O-PHOSPHOROTHIOATE) USING 2-NITROBENZYL GROUP AS A NEW S-PROTECTION

DOI: 10.1016/S0040-4039(01)80667-5

Source and publish data:

Tetrahedron Letters p. 3821 - 3824 (1989)

Update date:2022-07-31

Topics:

Authors:

Lesnikowski, Z.J.

Jaworska, M.M.

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Article abstract of DOI:10.1016/S0040-4039(01)80667-5

(Rp,Rp)- and (Sp,Sp)-diastereomers of thymidylyl(3',5')thymidylyl(3',5')thymidine di (O,O-phosphorothioate (6) were prepared in the stereospecific reaction of (Rp)- or (Sp)-isomer of 5'-O-monomethoxytritylthymidine 3'-O- (2) with 5'-OH activated 3'-O-acetylthymidine and subsequently with 5'-OH deprotected, 5'-OH activated derivative of resulted dinucleotide 3.

Full text of DOI:10.1016/S0040-4039(01)80667-5

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