126399-10-8

Upstream product

• 126399-03-9 (E)-(S)-5-Methoxy-2,4-dimethyl-6-phenyl-hex-2-enoic acid ethyl ester 
• 126399-03-9 cis/trans-(4S,5S)-ethyl-5-methoxy-2,4-dimethyl-6-phenylhex-2-enoate 

Downstream Products

• 134440-92-9 (2S,3S,4E,6E,8S,9S)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid 
• 134440-91-8 (2S,3S,8S,9S,4E,6E)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid methyl ester 
• 126399-06-2 ((E)-(4S,5S)-5-Methoxy-2,4-dimethyl-6-phenyl-hex-2-enyl)-triphenyl-phosphonium; bromide 
• 134440-91-8 (4Z,6Z)-(2S,3S,8S,9S)-3-tert-Butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 134440-91-8 (4Z,6E)-(2S,3S,8S,9S)-3-tert-Butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 134440-91-8 (2S,3S,8S,9S,4E,6Z)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid methyl ester 
• 134526-68-4 (2S,3S,8S,9S,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldecadienoic acid trifluoroacetate 
• 126399-11-9 cis/trans-(4S,5S)-1-bromo-5-methoxy-2,4-dimethyl-6-phenylhex-2-ene 

Relevant academic research and scientific papers

Stereocontrolled Synthesis of (2S,3S,8S,9S,4E,6E)-3-Amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic Acid (Adda), the Amino Acid Characteristic of Microcystins and Nodularin

(4R,5S)-4-Methyl-5-phenyloxazolidin-2-one has been used as a chiral template to construct the 8S and 9S chiral centres of (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid (Adda), the 2S and 3S centres being derived from D-asp

TOTAL SYNTHESIS OF ADDA, THE UNIQUE C20 AMINO ACID OF CYANOBACTERIAL HEPATOTOXINS

Synthetic (2S,3R)-3-Amino-4-hydroxy-2-methylbutanoic acid, γ-lactone, and (4S,5S)-2,4-dimethyl-5-methoxy-6-phenyl-2-hexen-1-ol were oxidized and linked to give (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid (Adda).