126403-57-4

Usage

Uses

Used in Pharmaceutical Industry:
8-Methoxy-5-Methyl-quinoline is used as an intermediate in the synthesis of 5-Methyl-7-chloro-8-hydroxy-quinoline, which is a key compound in the development of germicides. This allows for the creation of germicides that can be deposited in oily mediums, although their activity may be reduced compared to other formulations.

Upstream product

• 17012-44-1 chloro-5 methoxy-8 quinoleine 
• 917-54-4 methyllithium 
• 120-71-8 Cresidine 
• 107-02-8 acrolein 
• 95-84-1 3-amino-4-hydroxytoluene 
• 5541-67-3 5-methyl-8-quinolinol 
• 74-88-4 methyl iodide 

Downstream Products

• 5541-67-3 5-methyl-8-quinolinol 

Relevant academic research and scientific papers

4,4'-bipyridine as a unidirectional switching unit for a molecular pushing motor

A chirality switch in which the intrinsic chirality of a 4,4'-bipyridine is combined with a metal-ion-induced switching principle is described. In the uncomplexed state the 4,4'-bipyridine unit, which is linked to an S,S,S,S-configured cyclic imidazole peptide, is P-configured. The addition of zinc ions leads to a rotation around the C-C bond axis of the 4,4'-bipyridine and the Misomer of the metal complex is formed. By addition of a stronger complexing agent the metal ions are removed and the switch returns to its initial position. The combination of the chirality switch with a second switching unit allows the construction of a molecular pushing motor, which is driven chemically and by light. Motor drive: The combination of the intrinsic chirality of a 4,4'-bipyridine with a metal-ion-induced switching principle leads to a metal-ion-induced chirality switch that can also be used as a basic unit for a molecular pushing motor. Rotation around the C-C bond axis of the bipyridine, which is linked to a cyclic imidazole peptide, leads to switching between P and Misomers (see scheme).

Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors

Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

A SHORT AND CONVENIENT SYNTHESIS OF 5-ALKYL SUBSTITUTED 8-HYDROXYQUINOLINES

5-Chloro-8-methoxyquinoline undergoes rapid and reversible lithium-halogen exchange reaction with alkyllithiums to yield 5-substituted derivatives indirectly, whereas the reaction with phenyllithium is slower and 5-alkyl substituted compounds are formed by the direct addition of alkyl halides.