126410-44-4

Basic information

• Product Name: L-692048
• Synonyms: L-692048
• CAS NO: 126410-44-4
• Molecular Weight: 650.815
• Mol File: 126410-44-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-692048(CAS DataBase Reference)
• NIST Chemistry Reference: L-692048(126410-44-4)
• EPA Substance Registry System: L-692048(126410-44-4)

Safety Data

• Hazardous Substances Data: 126410-44-4(Hazardous Substances Data)

Upstream product

• 142526-87-2 5(S)-(Boc-amino)-4(S)-hydroxy-6-phenyl-2(R)-[(p-benzyloxyphenyl)methyl]-hexanoic acid 
• 140468-58-2 [(R)-1-((1S,2R)-2-Hydroxy-indan-1-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 7480-35-5 trans-1-aminoindan-2-ol 
• 7480-35-5 (+/-)-cis-1-amino-indan-2-ol 
• 138499-15-7 [(1S,2S,4R)-1-Benzyl-5-(4-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 140468-56-0 (L)-phenylalanine <2(R)-hydroxy-1(S)-indanyl>amide 
• 126410-42-2 5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-<(tert-butyldimethylsilyl)oxy>-6-phenyl-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanoic acid 
• 140468-55-9 2-phenyl-3a,8a-dihydro-8(H)-indeno<1,2-d>oxazole 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 

Downstream Products

• 138498-62-1 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-[1,1-dimethylethoxy-carbonylamino]-4(S)-hydroxy-6-phenyl-2(R)-(4-hydroxyphenylmethyl) hexanamide 
• 138483-77-9 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-<<3-(4-morpholinyl)propyl>oxy>phenyl>-2(R)-(phenylmethyl)hexanamide 
• 138483-79-1 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methyl>hexanamide 
• 138484-07-8 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-oxo-2-(4-morpholinyl)ethoxy>phenyl>methyl>hexanamide 
• 138483-82-6 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(1-oxothiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide 
• 138483-80-4 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-ethoxy>phenyl>methyl>hexanamide 
• 138483-83-7 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(1,1-dioxythiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide 
• 138483-84-8 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(4-methylpiperazin-1-yl)ethoxy>phenyl>methyl>hexanamide 
• 138483-81-5 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide 
• 138483-63-3 L-689502 
• 138498-60-9 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(1-piperidinyl)ethoxy>phenyl>methyl>hexanamide 
• 140468-60-6 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(4-oxo-4-morpholinyl)ethoxy>phenyl>methyl>hexanamide 
• 140468-61-7 {4-[(2R,4S,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-6-phenyl-hexyl]-phenoxy}-acetic acid ethyl ester 
• 139934-80-8 {4-[(2R,4S,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-6-phenyl-hexyl]-phenoxy}-acetic acid 

Relevant articles and documents

HIV protease inhibitors useful for the treatment of aids

Compounds of the form,ψ ψ A-G-Jψ ψ wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.ψ

Inhibitors of HIV protease

Novel dipeptide isosteres are the biotransformed products after incubation with rat liver slices. They inhibit HIV protease, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically

HIV protease inhibitors useful for the treatment of aids

[From equivalent EP0434365A2] Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are describe