138483-63-3

Usage

Uses

Used in Pharmaceutical Applications:
Tert-butyl (1S,2S,4R)-1-benzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-4-[4-(2-morpholin-4-ylethoxy)benzyl]-5-oxopentylcarbamate is utilized as a pharmaceutical compound for its potential therapeutic effects. The intricate molecular structure allows for targeted interactions with biological systems, making it a candidate for drug development.
Used in Materials Science:
In the field of materials science, tert-butyl (1S,2S,4R)-1-benzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-4-[4-(2-morpholin-4-ylethoxy)benzyl]-5-oxopentylcarbamate is employed as a component in the synthesis of advanced materials. Its chemical versatility contributes to the creation of new materials with specific properties, such as improved stability or reactivity.
Used in Organic Chemistry Research:
Tert-butyl (1S,2S,4R)-1-benzyl-2-hydroxy-5-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino-4-[4-(2-morpholin-4-ylethoxy)benzyl]-5-oxopentylcarbamate serves as a key intermediate in organic synthesis, facilitating the development of new chemical reactions and methodologies. Its unique structural features make it a valuable tool for exploring novel synthetic pathways and expanding the scope of organic chemistry.

Upstream product

• 3240-94-6 N-(2-chlorethyl)morpholine 
• 138498-62-1 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-[1,1-dimethylethoxy-carbonylamino]-4(S)-hydroxy-6-phenyl-2(R)-(4-hydroxyphenylmethyl) hexanamide 
• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 
• 140468-56-0 (L)-phenylalanine <2(R)-hydroxy-1(S)-indanyl>amide 
• 138499-15-7 [(1S,2S,4R)-1-Benzyl-5-(4-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 126410-44-4 L-692048 
• 140468-58-2 [(R)-1-((1S,2R)-2-Hydroxy-indan-1-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 140468-55-9 2-phenyl-3a,8a-dihydro-8(H)-indeno<1,2-d>oxazole 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 7480-35-5 trans-1-aminoindan-2-ol 
• 7480-35-5 (+/-)-cis-1-amino-indan-2-ol 
• 141018-43-1 {(1S,2S,4R)-1-Benzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-4-[4-(2-morpholin-4-yl-ethoxy)-benzyl]-5-oxo-pentyl}-carbamic acid tert-butyl ester 
• 126410-42-2 5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-<(tert-butyldimethylsilyl)oxy>-6-phenyl-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanoic acid 
• 142526-87-2 5(S)-(Boc-amino)-4(S)-hydroxy-6-phenyl-2(R)-[(p-benzyloxyphenyl)methyl]-hexanoic acid 

Downstream Products

• 140468-60-6 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(4-oxo-4-morpholinyl)ethoxy>phenyl>methyl>hexanamide 

Relevant academic research and scientific papers

Highly Diastereoselective Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isostere Inhibitors of HIV-1 Protease

The nonchelate enforced chiral amide enolates derived from 4-7 react with alkyl iodide and protected α-amino epoxide electrophiles to produce the HIV protease inhibitors 10 and 16-19 with high diastereoselectivity.

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1'phenyl substituents: X-ray crystal structure assisted design

By tethering of a polar hydrophilic group to the P1 or P1' substituent of a Phe-based hydroxyethylene isostere, the antiviral potency of a series of HIV protease inhibitors was improved. The optimum enhancement of anti-HIV activity was observed with the 4-morpholinylethoxy substituent. The substituent effect is consistent with a model derived from inhibitor docked in the crystal structure of the native enzyme. An X-ray crystal structure of the inhibited enzyme determined to 2.25 A verifies the modeling predictions.