943863-69-2

Basic information

• Product Name: ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE
• CAS NO: 943863-69-2
• Molecular Formula: C₁₃H₁₃FN₂O₂
• Molecular Weight: 248.25
• Mol File: 943863-69-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE(943863-69-2)
• EPA Substance Registry System: ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE(943863-69-2)

Safety Data

• Hazardous Substances Data: 943863-69-2(Hazardous Substances Data)

Upstream product

• 60-34-4 methylhydrazine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1224879-05-3 (Z)-ethyl 4-(4-fluorophenyl)-2-hydroxy-4-oxobut-2-enoate 
• 866588-11-6 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 943863-70-5 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxylic acid 
• 126417-81-0 (3-(4-fluorophenyl)-1-methyl-1H-5-pyrazolyl)amine 

Relevant articles and documents

Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage

A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell lines in vitro, superior to 5-FU. The most potent compound 10M selectively inhibited human hepatocellular carcinoma cells but not non-tumor liver cell proliferation in vitro, and significantly triggered SMMC-7721 cell apoptosis by cleavage of both PARP and caspase-3 in a concentration-dependent manner. Further study revealed that the potent activity in the cell growth inhibition and apoptosis induction effects of 10M were related to DNA damage and activation of the p53 signaling pathway. Moreover, 10M showed low acute toxicity to mice and significant growth inhibition of the hepatoma tumor in vivo.

1. 3, 5 - tri-substituted pyrazole compound and its preparation method and application

The invention discloses 1,3,5-trisubstituted pyrazole compounds, and a preparation method and application thereof. The structure of the compounds is shown as a general formula (I), and in the general formula (I), R1 is hydrogen, halogens, methyl or triflu

PYRAZOLOALKYL SUBSTITUTED IMIDAZO RING COMPOUNDS AND METHODS

Imidazo ring compounds, (e.g., imidazo[4,5-c]quinoline, 6,7,8,9-tetrahydro imidazo[4,5-c]quinoline, imidazo[4,5-c]naphthyridine, 6,7,8,9-tetrahydro imidazo[4,5-c]naphthyridine and imidazo[4,5-c]pyridine compounds) having a pyrazoloalkyl substituent at the