In healthy women, there was a 41 per cent fall in plasma bradykininogen 48 (36 to 60) hours before ovulation. Similarly, guinea pigs showed a 79 per cent fall 24 (18 to 30) hours before ovulation; recovery of normal values occurred by the time of ovulation itself. The 59 per cent fall in rats to...detailed
Incubation of bovine bradykininogen with urokinase-activated human plasmin produces kinin activity as demonstrated on the isolated guinea pig uterus. In terms of specific activity, the activation of bradykininogen appeared to be similar to that obtained with trypsin. A dose-response relationship...detailed
As a model for the study of cardiovascular shock, where the participation of bradykinin and related peptides could be expected, trypsin, kallikrein, and a crystalline proteinase of bacterial origin (Nagarse) have been employed. Experimental conditions were found in which hydrolysis of bradykinin...detailed