Activation of bovine bradykininogen (cas 12642-94-3) by human plasmin☆

Add time:08/17/2019    Source:sciencedirect.com

Incubation of bovine bradykininogen (cas 12642-94-3) with urokinase-activated human plasmin produces kinin activity as demonstrated on the isolated guinea pig uterus. In terms of specific activity, the activation of bradykininogen appeared to be similar to that obtained with trypsin. A dose-response relationship was evident. It is suggested that direct activation of kininogen by plasmin may constitute another route, apart from the more major kallikrein pathway, in the formation of kinin.

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