bradykininogen (cas 12642-94-3) and bradykinin in the cardiovascular shock produced by proteolytic enzymes☆

Add time:08/16/2019    Source:sciencedirect.com

As a model for the study of cardiovascular shock, where the participation of bradykinin and related peptides could be expected, trypsin, kallikrein, and a crystalline proteinase of bacterial origin (Nagarse) have been employed. Experimental conditions were found in which hydrolysis of bradykininogen (cas 12642-94-3) in vivo with concomitant appearance of bradykinin-like peptides in the blood could be demonstrated. These results substantiate the idea that the release of peptides of the bradykinin type is an important factor in the production of the hypotension by proteolytic enzymes. The extent of the mobilization of kinin peptides during the experimental procedure was assayed by the determination of alterations in the amount of their precursor-bradykininogen-in plasma, since only a small percentage of the precursor destroyed could be recovered as the active peptide.

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