126429-04-7

Upstream product

• 1373543-41-9 ethyl (2S,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate 
• 1373543-42-0 ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1373543-45-3 {(4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazol-4-yl}methanol 

Downstream Products

• 1373543-46-4 C₁₈H₂₀FNO₅S*ClH 
• 76639-93-5 (1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol 
• 73231-34-2 Florfenicol 

Relevant academic research and scientific papers

An efficient enantioselective synthesis of florfenicol based on sharpless asymmetric dihydroxylation

An efficient and highly enantioselective synthesis of florfenicol- via a new intermediate threo-dihydroxy ester, with a Sharpless asymmetric dihydroxylation as the key step, is reported. A ring-opening/reduction strategy avoids the formation of a chlorinated byproduct that occurs in Schumachers phenyloxazoline procedure. The overall yield of florfenicol by this new process is 23% based on 4-(methylsulfonyl)benzaldehyde. Georg Thieme Verlag Stuttgart · New York.