126441-90-5

Upstream product

• 328011-26-3 methyl 3-[(4-nitrophenyl)amino]-3-oxopropanoate 
• 941-55-9 4-toluenesulfonyl azide 
• 100-01-6 4-nitro-aniline 
• 85779-79-9 methyl 1-(4-nitrophenyl)-5-amino-1H-1,2,3-triazole-4-carboxylate 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 67-56-1 methanol 

Downstream Products

• 1442460-03-8 methyl 4-(4-nitrophenyl)-3-oxomorpholine-2-carboxylate 
• 1442460-02-7 methyl 2-(2-bromoethoxy)-3-[(4-nitrophenyl)amino]-3-oxopropanoate 

Relevant academic research and scientific papers

Studies towards the synthesis of alkyl N-(4-nitrophenyl)-3/2-oxomorpholine- 2/3-carboxylates

The syntheses of methyl 4-(4-nitrophenyl)-3-oxomorpholine-2-carboxylate (3a) and ethyl 4-(4-nitrophenyl)-2-oxomorpholine-3-carboxylate (5b), important building blocks for the synthesis of factor Xa inhibitor rivaroxaban analogs with potential dual antithrombotic activity, via Rh2(OAc) 4-catalyzed O-H and N-H carbene insertion reactions are described.

Synthesis of alkyl N-(4-nitrophenyl)-3/2-oxomorpholine-2/3-carboxylates by rhodium(II) acetate catalyzed O-H and N-H carbene insertion

The synthesis of methyl N-(4-nitrophenyl)-3-oxomorpholine-2-carboxylate and ethyl N-(4-nitrophenyl)-2-oxomorpholine-3-carboxylate, via rhodium(II) acetate catalyzed intermolecular O-H and intramolecular N-H carbene insertion, is described. The products represent new and versatile building blocks for the synthesis of bioactive compounds of pharmaceutical interest.