126456-38-0

Basic information

• Product Name: Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester
• CAS NO: 126456-38-0
• Molecular Formula: C33H40N2O6
• Molecular Weight: 560.69
• Mol File: 126456-38-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester(126456-38-0)
• EPA Substance Registry System: Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester(126456-38-0)

Safety Data

• Hazardous Substances Data: 126456-38-0(Hazardous Substances Data)

Upstream product

• 126410-52-4 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-(phenylmethyl)hexanamide 
• 140468-56-0 (L)-phenylalanine <2(R)-hydroxy-1(S)-indanyl>amide 
• 138499-15-7 [(1S,2S,4R)-1-Benzyl-5-(4-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 126410-42-2 5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-<(tert-butyldimethylsilyl)oxy>-6-phenyl-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanoic acid 
• 142526-87-2 5(S)-(Boc-amino)-4(S)-hydroxy-6-phenyl-2(R)-[(p-benzyloxyphenyl)methyl]-hexanoic acid 
• 140468-58-2 [(R)-1-((1S,2R)-2-Hydroxy-indan-1-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 140468-55-9 2-phenyl-3a,8a-dihydro-8(H)-indeno<1,2-d>oxazole 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 7480-35-5 trans-1-aminoindan-2-ol 
• 7480-35-5 (+/-)-cis-1-amino-indan-2-ol 

Downstream Products

• 138483-72-4 N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-<2-(4-morpholinyl)ethoxy>phenyl>-2(R)-(phenylmethyl)hexanamide 

Relevant articles and documents

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1'phenyl substituents: X-ray crystal structure assisted design

By tethering of a polar hydrophilic group to the P1 or P1' substituent of a Phe-based hydroxyethylene isostere, the antiviral potency of a series of HIV protease inhibitors was improved. The optimum enhancement of anti-HIV activity was observed with the 4-morpholinylethoxy substituent. The substituent effect is consistent with a model derived from inhibitor docked in the crystal structure of the native enzyme. An X-ray crystal structure of the inhibited enzyme determined to 2.25 A verifies the modeling predictions.