1264617-07-3Relevant academic research and scientific papers
Multicomponent cascade reactions: A novel and expedient approach to functionalized indoles by an unprecedented nucleophilic addition- heterocyclization-oxidative alkoxycarbonylation sequence
Gabriele, Bartolo,Veltri, Lucia,Salerno, Giuseppe,Mancuso, Raffaella,Costa, Mirco
, p. 3355 - 3363 (2011/03/17)
A novel multicomponent cascade process is reported, based on the sequential combination between an initial nucleophilic attack step to an imine moiety and a palladium-catalyzed oxidative heterocyclization-alkoxycarbonylation process. By this new process, five simple molecules [2-alkynylaniline imines, alcohol (ROH), carbon monoxide (CO), alcohol (ROH), and oxygen (O2)] are sequentially activated, selectively leading to high value-added functionalized indole derivatives in a single operation. Copyright
