126476-58-2

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 98-17-9 3-Trifluoromethylphenol 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 18739-07-6 3-(3-(trifluoromethyl)phenoxy)phenol 
• 156176-33-9 Acetic acid 2-{2,4-dioxo-5-[3-(3-trifluoromethyl-phenoxy)-benzyl]-3,4-dihydro-2H-pyrimidin-1-ylmethoxy}-ethyl ester 
• 188953-69-7 2-Thioxo-5-[3-(3-trifluoromethyl-phenoxy)-benzyl]-2,3-dihydro-1H-pyrimidin-4-one 
• 188953-71-1 5-[3-(3-Trifluoromethyl-phenoxy)-benzyl]-1H-pyrimidine-2,4-dione 
• 188953-58-4 3-[3-(3-Trifluoromethyl-phenoxy)-phenyl]-propionic acid ethyl ester 

Relevant academic research and scientific papers

Inhibition of uridine phosphorylase. Synthesis and structure-Activity relationships of aryl-substituted 1-((2-hydroxyethoxy)methyl)-5-(3- phenoxybenzyl)uracil

Structure-activity relationship studies on a series of 1-((2- hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver uridine phosphorylase have led to compounds with IC50s as low as 1.4 nM. The two most potent compounds, 10j (3-cyanophenoxy) and 11f (3-chlorophenoxy) were tested in vive for effects on steady-state concentrations of circulating uridine in mice and rats. Both compounds were substantially more efficacious than BAU (5-benzylacyclouridine) both in vitro and in vivo.

Novel aryl ether sulfones

Disclosed is an aryl ether sulfone of the following formula: STR1 wherein R1 is independently in each occurrence hydrogen, alkyl, alkoxy, aryl, aryloxy, polyhaloaryl, polyhaloaryloxy, polyhaloalkylaryl, or polyhaloalkylaryloxy, R2 is