126505-17-7

Upstream product

• 2642-81-1 1,1-bis(p-chlorophenyl)ethene 
• 34636-09-4 benzyldiisopropylamine 
• 108-88-3 toluene 
• 100-42-5 styrene 
• 1143-92-6 bis-(4-chlorophenyl)diazomethane 

Relevant academic research and scientific papers

Nickel-Catalyzed Benzylation of Aryl Alkenes with Benzylamines via C-N Bond Activation

We have developed the first example of nickel-catalyzed Heck-type benzylation of aryl olefins with various benzylamines as benzyl electrophiles, and the benzylic C-N bond cleavage was efficiently promoted by the amine-I2 charge transfer complex (CT complex). The combination of low-cost NiCl2 and I2 has been found to facilitate Heck reaction of tertiary benzylamines and alkenes into various benzyl-substituted alkenes in good to excellent yields. This unconventional Heck reaction is proposed to go through initially the formation of a benzylic radical via oxidative addition of the C-N bond with Ni(0), then capturing by aryl alkene via radical addition, followed by single-electron transfer redox and proton abstraction without oxidant and external base.

Direct difunctionalization of activated alkynes via domino oxidative benzylation/1,4-aryl migration/decarboxylation reactions under metal-free conditions

The oxidative difunctionalization of aryl alkynoates via benzyl radical initiated intramolecular 1,4-aryl migration and decarboxylation tandem process was developed in the presence of tert-butyl hydroperoxide as an oxidant, which provides a direct and selective route to a variety of trisubstituted alkenes from simple toluene derivatives and aryl alkynoates.