1265146-06-2

Upstream product

• 87694-54-0 tert-butyl ((2S,3R)-3-(benzyloxy)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate 
• 79069-55-9 tert-butyl [(2S,3R)-3-(benzyloxy)-1-oxobutan-2-yl]carbamate 
• 141120-04-9 tert-butyl N-[(tert-butoxy)carbonyl]-N-(prop-2-yn-1-yl)carbamate 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1265145-95-6 C₂₉H₄₄N₂O₈ 

Relevant academic research and scientific papers

Pyrrole-based scaffolds for turn mimics

Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 β-turn and with an inverse γ-turn.(Figure Presented)