87694-54-0Relevant academic research and scientific papers
Synthesis of new chiral peptide nucleic acid (PNA) monomers by a simplified reductive amination method
Falkiewicz, Bogdan,Kowalska, Katarzyna,Kolodziejczyk, Aleksandra S.,Wisniewski, Kazimierz,Lankiewicz, Leszek
, p. 353 - 361 (1999)
The aim of this work was the preparation of four new peptide nucleic acid (PNA) monomer backbone by reductive amination of N(α)-Boc-protected chiral amino aldehydes, derived from Leu, Phe, Tyr(Bzl), and Thr(Bzl), with methyl glycinate. To the crude 2-subs
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile
Ripa, Lena,Edman, Karl,Dearman, Matthew,Edenro, Goran,Hendrickx, Ramon,Ullah, Victoria,Chang, Hui-Fang,Lepist?, Matti,Chapman, Dave,Geschwindner, Stefan,Wissler, Lisa,Svanberg, Petter,Lawitz, Karolina,Malmberg, Jesper,Nikitidis, Antonios,Olsson, Roine I.,Bird, James,Llinas, Antoni,Hegelund-Myrb?ck, Tove,Berger, Markus,Thorne, Philip,Harrison, Richard,K?hler, Christian,Drmota, Tomas
supporting information, p. 1785 - 1799 (2018/03/21)
Synthetic glucocorticoids (GC) are essential for the treatment of a broad range of inflammatory diseases. However, their use is limited by target related adverse effects on, e.g., glucose homeostasis and bone metabolism. Starting from a nonsteroidal GR li
Pyrrole-based scaffolds for turn mimics
Ko, Eunhwa,Burgess, Kevin
supporting information; experimental part, p. 980 - 983 (2011/04/22)
Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 β-turn and with an inverse γ-turn.(Figure Presented)
