87694-54-0Relevant articles and documents
Synthesis of new chiral peptide nucleic acid (PNA) monomers by a simplified reductive amination method
Falkiewicz, Bogdan,Kowalska, Katarzyna,Kolodziejczyk, Aleksandra S.,Wisniewski, Kazimierz,Lankiewicz, Leszek
, p. 353 - 361 (1999)
The aim of this work was the preparation of four new peptide nucleic acid (PNA) monomer backbone by reductive amination of N(α)-Boc-protected chiral amino aldehydes, derived from Leu, Phe, Tyr(Bzl), and Thr(Bzl), with methyl glycinate. To the crude 2-subs
Pyrrole-based scaffolds for turn mimics
Ko, Eunhwa,Burgess, Kevin
supporting information; experimental part, p. 980 - 983 (2011/04/22)
Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 β-turn and with an inverse γ-turn.(Figure Presented)