1266246-51-8

Basic information

• Product Name: 1-(3-(4-methoxyphenoxy)propyl)-6-phenyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride
• CAS NO: 1266246-51-8
• Molecular Weight: 389.885
• Mol File: 1266246-51-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-(4-methoxyphenoxy)propyl)-6-phenyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(4-methoxyphenoxy)propyl)-6-phenyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride(1266246-51-8)
• EPA Substance Registry System: 1-(3-(4-methoxyphenoxy)propyl)-6-phenyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride(1266246-51-8)

Safety Data

• Hazardous Substances Data: 1266246-51-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 100841-00-7 3-(4-methoxyphenoxy)propan-1-amine 
• 127099-85-8 N-Cyanoguanidine 

Relevant articles and documents

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates

The design, synthesis and biological evaluation of a series of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines is described. These compounds exhibited in vitro antiplasmodial activity in the low nanomolar range against both drug sensitive and drug resistant strains of P. falciparum, with 1-(3-(2,4-dichlorophenoxy)propyl)-6-phenyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride identified as the most potent compound from this series against the drug resistant FCR-3 strain (IC50 2.66 nM). The compounds were not toxic to mammalian cells at therapeutic concentrations and were shown to be inhibitors of parasitic DHFR in a biochemical enzyme assay.