1266331-36-5

Upstream product

• 123-30-8 4-amino-phenol 
• 36309-42-9 4-(trimethylsilyloxy)aniline 
• 57709-61-2 1,10-phenanthroline-2,9-dicarboxylic acid 
• 484-11-7 2.9-dimethyl-1,10-phenanthroline 

Downstream Products

• 1301127-07-0 N,N'-bis(phenyl-4-ethoxydimethylamino)-1,10-phenanthroline-2,9-carboxamide 
• 1266331-37-6 N,N'-bis(phenyl-4-ethoxypiperidine)-1,10-phenanthroline-2,9-carboxamide 
• 1266331-38-7 N,N'-bis(phenyl-4-ethoxypyrrole)-1,10-phenanthroline-2,9-carboxamide 
• 1301127-06-9 N,N'-bis(phenyl-4-ethoxymorpholine)-1,10-phenanthroline-2,9-carboxamide 

Relevant academic research and scientific papers

Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

Four new di-substituted phenanthroline-based compounds a-d have been designed and prepared, and they have been shown to induce the formation of anti-parallel structure of human telomeric G-quadruplex DNA by CD spectra. FRET assay indicates that the melting temperature increases (ΔTm values) of G-quadruplex in buffer (pH 7.4) containing 100 mM NaCl are 31.6, 34.6, 17.8 and 32.6°C for the compounds (1.0 μM) a, b, c and d, respectively. Competitive FRET assay shows that the four compounds exhibit a high G-quadruplex DNA selectivity over duplex DNA. Three of the compounds are the potent telomerase inhibitors and HeLa cell proliferation inhibitors.