1266682-70-5Relevant academic research and scientific papers
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids
Frolova, Liliya V.,Magedov, Igor V.,Romero, Anntherese E.,Karki, Menuka,Otero, Isaiah,Hayden, Kathryn,Evdokimov, Nikolai M.,Banuls, Laetitia Moreno Y.,Rastogi, Shiva K.,Smith, W. Ross,Lu, Shi-Long,Kiss, Robert,Shuster, Charles B.,Hamel, Ernest,Betancourt, Tania,Rogelj, Snezna,Kornienko, Alexander
, p. 6886 - 6900 (2013/10/01)
We developed synthetic chemistry to access the marine alkaloid rigidins and over 40 synthetic analogues based on the 7-deazaxanthine, 7-deazaadenine, 7-deazapurine, and 7-deazahypoxanthine skeletons. Analogues based on the 7-deazahypoxanthine skeleton exh
One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D
Frolova, Liliya V.,Evdokimov, Nikolai M.,Hayden, Kathryn,Malik, Indranil,Rogelj, Snezna,Kornienko, Alexander,Magedov, Igor V.
, p. 1118 - 1121 (2011/05/15)
Privileged medicinal scaffolds based on the structures of tetra-and pentasubstituted 2-aminopyrroles were prepared via one-pot multicomponent reactions of structurally diverse aldehydes and N-(aryl-, hetaryl-, alkylsulfonamido)acetophenones with activated methylene compounds. This methodology was used in a four-step synthesis of alkaloids rigidins A, B, C, and D in overall yields of 61%, 58%, 60%, and 53%, respectively. Of these, rigidins B, C, and D were synthesized for the first time.(Figure Presented)
