126679-00-3Relevant academic research and scientific papers
Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-Receptor agonist properties
Barraclough, Paul,Bolofo, Mary L.,Giles, Heather,Gillam, Janet,Harris, C. John,Kelly, Michael G.,Leff, Paul,McNeill, Alan,Robertson, Alan D.,Stepney, Ray J.,Whittle, Brendan J. R.
, p. 81 - 90 (1996)
The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic imidazolidinone analogues are described. Compounds 7 (BW587C), 8 (BW480C85), and 9 (BW572C85) were found to be potent inhibitors of human platelet aggregation and selective DP-receptor agonists in washed platelet and jugular vein isolated tissue assays.
PYRIDO PYRIMIDINES
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, (2012/07/28)
Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
INHIBITORS OF AKT ACTIVITY
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Page/Page column 124, (2008/06/13)
Invented are novel 1 H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
