126694-06-2Relevant academic research and scientific papers
Total synthesis of brevetoxin A: Part 1: First generation strategy and construction of BCD ring system
Nicolaou,Bunnage, Mark E.,McGarry, Daniel G.,Shi, Shuhao,Somers, Patricia K.,Wallace, Paul A.,Chu, Xin-Jie,Agrios, Konstantinos A.,Gunzner, Janet L.,Yang, Zhen
, p. 599 - 617 (2007/10/03)
Discussed herein is our first generation strategy for the total synthesis of brevetoxin A. This approach relies upon dissection of the molecule at the nine-membered ring site (ring E). A Wittig coupling of requisite polycyclic fragments 3 and 4 followed b
Total synthesis of brevetoxin A: Part 3: Construction of GHIJ and BCDE ring systems
Nicolaou,Shi, Guo-Qiang,Gunzner, Janet L.,Gaertner, Peter,Wallace, Paul A.,Ouellette, Michael A.,Shi, Shuhao,Bunnage, Mark E.,Agrios, Konstantinos A.,Veale, Chris A.,Hwang, Chan-Kou,Hutchinson, John,Prasad,Ogilvie, William W.,Yang, Zhen
, p. 628 - 645 (2007/10/03)
Successful syntheses of highly complex intermediates 2 (GHIJ ring system) and 3 (BCDE ring system) for the total synthesis of brevetoxin A (1) are described. Several of our methodologies were utilized to achieve this goal: i) hydroxy epoxide cyclizations
