1267390-56-6Relevant academic research and scientific papers
Method of preparing alpha-ketoamide with micro-reaction apparatus
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Paragraph 0036-0037; 0054-0055; 0062-0063, (2018/05/07)
The invention discloses a method of preparing alpha-ketoamide with a micro-reaction apparatus, which includes the following steps: 1) mixing an alpha-methyl benzyl alcohol compound, an amine compound,an acid binding agent, 2,2,6,6-tetramethyl piperidine oxide and dichloromethane to obtain a heterogeneous solution; 2) mixing the heterogeneous solution with an organic iron catalyst solution to forma mixture solution, and respectively meanwhile pumping the mixture solution and oxygen gas into a micro-reactor in the micro-reaction apparatus to form a gas-liquid-solid mixture, and performing a reaction, after the reaction is finished, collecting an effluent liquid to obtain the alpha-ketoamide (III). With the organic iron catalyst for catalytically synthesizing the alpha-ketoamide, mixing status of the reactants is improved; the organic iron catalyst is better than ferric trichloride in solubility in the solvent, so that a problem of pipe blocking due to aggregation of ferric trichlorideparticles, thus accelerating homogenization of the system. The organic iron catalyst enables reaction conditions to be more gentle, reaction temperature being only 25-45 DEG C.
Copper-catalyzed aerobic oxidative cross-dehydrogenative coupling of amine and α-carbonyl aldehyde: A practical and efficient approach to α-ketoamides with wide substrate scope
Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,Jiao, Ning
supporting information; experimental part, p. 3280 - 3283 (2012/07/31)
A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with α-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various α-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of α-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.
Copper-catalyzed aerobic oxidative coupling of aryl acetaldehydes with anilines leading to α-ketoamides
Zhang, Chun,Xu, Zejun,Zhang, Liangren,Jiao, Ning
supporting information; experimental part, p. 11088 - 11092 (2012/02/02)
Efficient and practical: The title reaction provides an efficient route to α-ketoamides compounds, which are ubiquitous structural units in a number of biologically active compounds. N-substituted anilines are suitable substrates for this transformation.
