1267460-48-9

Upstream product

• 1241049-25-1 C₁₇H₁₅NO₂ 
• 768-60-5 4-methoxyphenylacetylen 
• 75-36-5 acetyl chloride 
• 157869-15-3 2-((4-methoxyphenyl)ethynyl)aniline 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 693794-65-9 1-[2-(4-methoxyphenyl)-1H-indol-1-yl]ethanone 
• 1267460-83-2 (Z)-4-(4-methoxybenzylidene)-2-methyl-4H-3,1-benzoxazine 
• 1224728-80-6 1-(3-(4-methoxyphenyl)-1H-indol-1-yl)ethan-1-one 
• 133437-40-8 1-(2-(4-methoxyphenyl)-1H-indol-3-yl)ethanone 

Relevant academic research and scientific papers

PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramolecular hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1–2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates.

Palladium-catalyzed highly regio-and stereoselective synthesis of 4-alkylidene-4 H -3,1-benzoxazines from N -Acyl-o -alkynylanilines

The highly regio-and stereoselective 6-exo-dig mode cyclization of N-acyl-o-alkynylanilines producing 4-alkylidene-3,1-benzoxazines occurred unpredictably by use of a proper catalyst [Pd(OAc)2] and an effective additive (acetic acid) under suit

Multicatalytic one-pot reaction of 1-(2-alkynylphenyl)ketoximes for generation of indole derivatives

Multicatalytic one-pot Beckmann rearrangement/intramolecular cyclization/halogenation reaction of 1-(2-alkynylphenyl)ketoxime is reported, leading to the expected indole derivatives in good yield.