126764-32-7

Usage

Derivative of pyrazole-4-carboxaldehyde

yes, with two methyl groups and a trifluoroethoxy group added

Common uses

pharmaceutical and agrochemical industries as a building block for the synthesis of biologically active compounds

Value

intermediate for the production of new drugs and pesticides, used in research and development of new chemical entities

Potential applications

materials science and organic synthesis.

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 27006-76-4 5-chloro-4-formyl-1,3-dimethylpyrazole 

Relevant academic research and scientific papers

Stereoselective synthesis and antifungal activities of (E)-α- (methoxyimino)benzeneacetate derivatives containing 1,3,5-substituted pyrazole ring

Thirteen novel (E)-α-(methoxyimino)benzeneacetate derivatives, the analogues of strobilurins, which contain two pharmacophoric substructures of the methyl (E)-methoxyiminoacetate moiety and 1,3,5-substituted pyrazole ring, were stereoselectively synthesized. It was found that the coupling reaction could give stereoselectively (E:Z ca. 14:1) the key intermediate material (E)-methyl 2-(hydroxyimino)-2-o-tolyl acetate (2). An X-ray crystallographic structure determination was carried out in a representative product. The preliminary bioassays indicated that all of the compounds 1 showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola, and Bipolaris mayclis.

ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES

Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides. Also claimed is a process for the preparation of compounds of the formula I, wherein m is 2 and n is 1, and the other substituents are defined as in claim 1, formula (Ia) by reacting a compound of the formula Ia in a single step or stepwise in succession with compounds of the formula R5-X and/or R6-X, wherein R5 and R6 are as defined in claim 1, and X is a leaving group, and a process for the preparation of compounds of the formula I, wherein R6 is C1--C10alkyl or halogen, m is 2 and n is 1, and the other substituents are defined as in claim 1, formula (Ib) by reacting a compound of the formula 1b with a compound of the formula R5-X, wherein R5 is as defined in claim 1, and X is a leaving group, and a process for the preparation of compounds of the formula I, wherein R5 is chlorine, bromine or iodine, m is 1 or 2, and n is 1, and the other substituents are defined as in claim 1, formula (Ic) by reacting a compound of the formula le with an N- halosuccinimide and an oxidising agent.