126771-39-9

Upstream product

• 63495-42-1 Boc-Tyr(Cl₂-Bzl)-OSu 
• 129398-66-9 Z(OMe)-Gly-Phe-Met(O)-OBzl 
• 129398-67-0 Z(OMe)-Gly-Gly-Phe-Met(O)-OBzl 
• 100-39-0 benzyl bromide 
• 78452-08-1 Z(OMe)-Phe-OSu 
• 129398-65-8 Z(OMe)-Phe-Met(O)-OBzl 
• 129398-79-4 Z(OMe)-Met(O)-OBzl 
• 73285-38-8 Z(OM₄e)-Met(O)-OH 

Downstream Products

• 129398-68-1 Boc-Tyr(Cl₂Bzl)-Gly-Gly-Phe-Met-OBzl 
• 58569-55-4 met-enkephalin 

Relevant academic research and scientific papers

Sulphur Trioxide/Thiol: A Novel System for the Reduction of Methionine Sulphoxide

A new method for the effective reduction of methionine sulphoxide in protected peptides with sulphur trioxide and thiol has been developed.In practice, a combination of dimethylformamide-sulphur trioxide complex and ethane-1,2-dithiol was found effective, the presence of pyridine in the reaction medium being found necessary for the reduction to proceed.Methionine sulphoxide in two types of protected methionine-enkephalins was efficiently reduced to methionine by this reduction system at 20 deg C in an hour.The (p-methylsulphinyl)benzyl protecting group was also reduced to (p-methylthio)benzyl simultaneously with the reduction of methionine sulphoxide.Subsequent deprotection afforded methionine-enkephalin of high purity in each case.