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Met-Enkephaline58569-55-4Sufficient supply high-quality Manufactor
Cas No: 58569-55-4
No Data No Data Metric Ton/Day Sichuan Jisheng BioPharmaceutical Co., Ltd. Contact Supplier
Tyrosylglycyl-glycyl-phenylalanyl-methionine
Cas No: 58569-55-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Methionine enkephalin manufacturer/supplier
Cas No: 58569-55-4
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
H-Tyr-Gly-Gly-Phe-Met-OH
Cas No: 58569-55-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Manufacturer supply CAS 58569-55-4 with best quality
Cas No: 58569-55-4
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
1-5-Adrenorphin (human)(9CI) 58569-55-4
Cas No: 58569-55-4
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
High Purity Met-Enkephalin Cas No: 58569-55-4
Cas No: 58569-55-4
USD $ 1.0-3.0 / Gram 10 Gram 1000 Kilogram/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
Pharma Grade PeptideTop Quality Cas 58569-55-4 Met-Enkephaline
Cas No: 58569-55-4
No Data 1 Gram 10 Kilogram/Month Wuhan Wonda Pharm Limited Contact Supplier
1-5-Adrenorphin (human)(9CI)
Cas No: 58569-55-4
No Data No Data No Data Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
Met-Enkephalin |[MET5]
Cas No: 58569-55-4
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58569-55-4 Usage

InChI:InChI=1/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1

58569-55-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid

1.2 Other means of identification

Product number -
Other names MET-enkephalin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58569-55-4 SDS

58569-55-4Synthetic route

(S)-2-{(S)-2-[2-(2-{(S)-3-[4-(4-Bromo-phenoxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methanesulfinyl-butyric acid

(S)-2-{(S)-2-[2-(2-{(S)-3-[4-(4-Bromo-phenoxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methanesulfinyl-butyric acid

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With p-cresol; dimethylsulfide; hydrogen fluoride at 0℃; for 1h;92%
boc-Tyr-Gly-Gly-Phe-Met-OH
59481-77-5

boc-Tyr-Gly-Gly-Phe-Met-OH

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride; acetic acid for 1h;90%
With hydrogenchloride In acetic acid for 0.5h;85%
Boc-Tyr-Gly-Gly-Phe-Met-OBut
82362-16-1

Boc-Tyr-Gly-Gly-Phe-Met-OBut

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With methyl-phenyl-thioether; trifluoroacetic acid for 1h; Ambient temperature;74%
C17H13NO10S2(2-)*2Na(1+)

C17H13NO10S2(2-)*2Na(1+)

C20H19NO10S3(2-)*2Na(1+)

C20H19NO10S3(2-)*2Na(1+)

C24H19NO10S2(2-)*2Na(1+)

C24H19NO10S2(2-)*2Na(1+)

C24H19NO11S2(2-)*2Na(1+)

C24H19NO11S2(2-)*2Na(1+)

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Stage #1: C20H19NO10S3(2-)*2Na(1+) With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; acetonitrile at 20℃; for 0.75h;
Stage #2: With ethanolamine In water for 0.166667h;
Stage #3: C17H13NO10S2(2-)*2Na(1+); C24H19NO10S2(2-)*2Na(1+); C24H19NO11S2(2-)*2Na(1+) Further stages;
63%
Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb
129398-74-9

Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With 3,5-dimethylmethoxybenzene; ethane-1,2-dithiol; trifluoroacetic acid 1) 0 deg C, 120 min, 2) 20 deg C, 60 min;57%
Boc-Tyr(Cl2Bzl)-Gly-Gly-Phe-Met-OBzl
129398-68-1

Boc-Tyr(Cl2Bzl)-Gly-Gly-Phe-Met-OBzl

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; methyl-phenyl-thioether; ethane-1,2-dithiol; 3-methyl-phenol; trifluoroacetic acid at 0℃; for 1.5h;49%
N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine
148715-90-6

N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 6h;40%
Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met
62530-43-2

Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride; ethane-1,2-dithiol; methoxybenzene In 1,4-dioxane for 1h; Ambient temperature; Yield given;
Z-Tyr(Bzl)-Gly-Gly-Phe-Met
74937-32-9

Z-Tyr(Bzl)-Gly-Gly-Phe-Met

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With methyl-phenyl-thioether In trifluoroacetic acid at 25℃; for 4h; Yield given;
methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine
81649-52-7

methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide 1.) methanol, water, 4 h, 2.) AcOH, 45 min; Yield given. Multistep reaction;
Z-Tyr-Gly-Gly-Phe-Hcy(Bzl)-OBzl
97512-82-8

Z-Tyr-Gly-Gly-Phe-Hcy(Bzl)-OBzl

methyl iodide
74-88-4

methyl iodide

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With sodium 1.) NH3 liq., -70 deg C, 2.) hexane-NH3, -70 -> -25 deg C, 1 h; Yield given. Multistep reaction;
methionine-enkephalin sulfoxide
60283-51-4

methionine-enkephalin sulfoxide

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With ammonium iodide; dimethylsulfide In trifluoroacetic acid at 0℃;
BocMet-R, Boc-amino acids

BocMet-R, Boc-amino acids

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Yield given; Multistep reaction;
phospho-Tyr-Gly-Gly-Phe-Met-OH

phospho-Tyr-Gly-Gly-Phe-Met-OH

A

met-enkephalin
58569-55-4

met-enkephalin

B

O-phosphono-L-tyrosine
21820-51-9

O-phosphono-L-tyrosine

C

L-tyrosine
60-18-4

L-tyrosine

D

[des-tyr1]-methionine enkephalin
61370-88-5

[des-tyr1]-methionine enkephalin

Conditions
ConditionsYield
With aminopeptidase M (EC3.4.11.2); 2-amino-2-hydroxymethyl-1,3-propanediol at 37℃; for 1h; pH=7.02; Kinetics; Hydrolysis;
-enkephalyl-arg6-phe7

-enkephalyl-arg6-phe7

A

L-arginyl-L-phenylalanine
2047-13-4

L-arginyl-L-phenylalanine

B

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With angiotensin I converting enzyme In various solvent(s) at 37℃; pH=7.75; Kinetics;
-enkephalyl-arg6-phe7

-enkephalyl-arg6-phe7

A

YG
673-08-5

YG

B

met-enkephalin
58569-55-4

met-enkephalin

C

tyrosylglycylglycine
21778-69-8

tyrosylglycylglycine

D

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With membrane fraction In various solvents at 37℃; for 1h; pH=7.4; Product distribution; Further Variations:; Reagents;
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Val

Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Val

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: NMM / dimethylformamide / 0.17 h / -15 °C
2: NMM / dimethylformamide / 20 h / -20 °C
3: 90 percent / 1.5 N HCl/AcOH
4: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
5: 95 percent / 1.5 N HCl/AcOH / 1 h
6: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
7: 86 percent / 0.5 M NaOH / acetone / 1.5 h
8: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine
40290-63-9

Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / 1.5 N HCl/AcOH
2: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
3: 95 percent / 1.5 N HCl/AcOH / 1 h
4: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
5: 86 percent / 0.5 M NaOH / acetone / 1.5 h
6: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Multi-step reaction with 5 steps
1: 98 percent / 4 M HCl / dioxane / 0.75 h
2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
3: 91 percent / 2 M HCl / acetic acid / 0.75 h
4: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
5: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 8 steps
1: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl / 1.) room temp., 5 h, 2.) Et2O
2: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h
3: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
4: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h
5: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
6: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
7: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
8: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate
60566-44-1

methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 0.5 M NaOH / acetone / 1.5 h
2: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester
70035-45-9

N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / 1.5 N HCl/AcOH / 1 h
2: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
3: 86 percent / 0.5 M NaOH / acetone / 1.5 h
4: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / 2 M HCl / acetic acid / 0.75 h
2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
3: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 4 steps
1: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
2: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
3: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
4: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
Boc-Phe-O-COO-isoBu
67729-36-6, 60398-40-5

Boc-Phe-O-COO-isoBu

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NMM / dimethylformamide / 20 h / -20 °C
2: 90 percent / 1.5 N HCl/AcOH
3: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
4: 95 percent / 1.5 N HCl/AcOH / 1 h
5: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
6: 86 percent / 0.5 M NaOH / acetone / 1.5 h
7: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine
70035-46-0

hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
2: 86 percent / 0.5 M NaOH / acetone / 1.5 h
3: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Multi-step reaction with 2 steps
1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
2: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 3 steps
1: N-methylmorpholine, 2,6-luditine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h
2: 91 percent / aq. NaOH / dimethylformamide / 6 h
3: 40 percent / aq. HCl / dioxane / 6 h
View Scheme
Multi-step reaction with 3 steps
1: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
2: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
3: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
L-phenylalaninyl-L-methionine methyl ether p-toluenesulfonate

L-phenylalaninyl-L-methionine methyl ether p-toluenesulfonate

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
2: 95 percent / 1.5 N HCl/AcOH / 1 h
3: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
4: 86 percent / 0.5 M NaOH / acetone / 1.5 h
5: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 90 percent / N,N'-dicyclohexylcarbodiimide (DCCI) / tetrahydrofuran / Ambient temperature
2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
3: 98 percent / 4 M HCl / dioxane / 0.75 h
4: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
5: 91 percent / 2 M HCl / acetic acid / 0.75 h
6: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
7: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 4 steps
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 1 min, 2.) -10 deg C, 30 min; 20 deg C, 2 h
2: 95 percent / 4.1 M HCl / dioxane / 4 h / 20 °C
3: 1.) 4.1 M HCl, isopentyl nitrite, 2.) Et3N / 1.) DMF, -20 deg C, 1 h, 2.) -30 deg C, 1 h; 4 deg C, 21 h
4: 1.) Na / 1.) NH3 liq., -70 deg C, 2.) hexane-NH3, -70 -> -25 deg C, 1 h
View Scheme
Multi-step reaction with 9 steps
1: 1)N-methylmorpholine, 1-β-napthalenesulphonyloxybenzotriazole / 1)EtOAc, RT, 1.5h 2) 12h RT
2: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl / 1.) room temp., 5 h, 2.) Et2O
3: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h
4: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
5: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h
6: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
7: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
8: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
9: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 8 steps
1.1: N,N-dimethyl-formamide / 20 °C
2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / pH 7
2.2: 4 h / 0 - 20 °C
3.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 0.25 h / 20 °C
4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / pH 7
4.2: 0 °C
4.3: 4 h / 0 - 20 °C
5.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 1 h / 20 °C
6.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C
6.3: 4 h / 0 - 20 °C
7.1: palladium 10% on activated carbon / methanol / 0.33 h / 20 °C
8.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 0.5 h / 0 °C
View Scheme
hydrochloride of methyl ester of L-phenylalanyl-L-methionine
40290-65-1

hydrochloride of methyl ester of L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
2: 91 percent / 2 M HCl / acetic acid / 0.75 h
3: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
4: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 7 steps
1: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h
2: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
3: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h
4: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
5: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
6: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
7: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime
81638-94-0

O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
2: 98 percent / 4 M HCl / dioxane / 0.75 h
3: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
4: 91 percent / 2 M HCl / acetic acid / 0.75 h
5: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
6: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
N-benzyloxycarbonyl-O-benzyl-L-tyrosine
86827-18-1, 92455-53-3, 16677-29-5

N-benzyloxycarbonyl-O-benzyl-L-tyrosine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dicyclohexylcarbodi-imide
4: thioanisole / trifluoroacetic acid / 4 h / 25 °C
View Scheme
N-(O-benzyl-N-benzyloxycarbonyl-L-tyrosyl)-glycine ethyl ester
21869-36-3

N-(O-benzyl-N-benzyloxycarbonyl-L-tyrosyl)-glycine ethyl ester

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
3: thioanisole / trifluoroacetic acid / 4 h / 25 °C
View Scheme
Z-Tyr(Bzl)-Gly-N2H3
74916-75-9

Z-Tyr(Bzl)-Gly-N2H3

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: thioanisole / trifluoroacetic acid / 4 h / 25 °C
View Scheme
fluorescein isothiocyanate
3326-32-7, 27072-45-3

fluorescein isothiocyanate

met-enkephalin
58569-55-4

met-enkephalin

C48H46N6O12S2

C48H46N6O12S2

Conditions
ConditionsYield
With N-ethylmorpholine; In N,N-dimethyl-formamide at 20℃; for 24h;

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