1268264-10-3 Usage
Uses
Used in Anticancer Applications:
Zgwatinib is used as an anticancer agent for targeting the c-MET protein, which is often overexpressed or dysregulated in various types of cancer. By inhibiting c-MET, Zgwatinib can effectively block the neoplastic effects associated with this protein, leading to the suppression of tumor growth and progression.
Used in Drug Development:
Zgwatinib is used as a key component in the development of novel cancer therapies, particularly for those targeting the c-MET signaling pathway. Its selective inhibition of c-MET makes it a valuable tool for researchers and pharmaceutical companies in the development of targeted cancer treatments.
Used in Clinical Trials:
Zgwatinib is used as a test compound in clinical trials to evaluate its safety, efficacy, and potential side effects when used as a cancer treatment. These trials are essential for determining the appropriate dosage, administration methods, and overall effectiveness of Zgwatinib in treating specific types of cancer.
Used in Combination Therapies:
Zgwatinib is used in combination with other cancer treatments, such as chemotherapy or radiation therapy, to enhance the overall therapeutic effect. By targeting the c-MET protein, Zgwatinib may help to sensitize cancer cells to other treatments, potentially improving patient outcomes and response rates.
Used in Research and Preclinical Studies:
Zgwatinib is used as a research tool in preclinical studies to better understand the role of c-MET in cancer development and progression. These studies can provide valuable insights into the molecular mechanisms underlying c-MET's involvement in cancer and help to identify potential biomarkers for patient selection and treatment response.
Check Digit Verification of cas no
The CAS Registry Mumber 1268264-10-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,8,2,6 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1268264-10:
(9*1)+(8*2)+(7*6)+(6*8)+(5*2)+(4*6)+(3*4)+(2*1)+(1*0)=163
163 % 10 = 3
So 1268264-10-3 is a valid CAS Registry Number.
1268264-10-3Relevant academic research and scientific papers
Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors
Wang, Yuanxiang,Ai, Jing,Liu, Gang,Geng, Meiyu,Zhang, Ao
, p. 5930 - 5933 (2011/10/08)
An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedlaender's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.
Synthesis and c-met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: Identification of 3-(4-acetylpiperazin-1-yl)-5- (3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent
Wang, Yuanxiang,Ai, Jing,Wang, Ying,Chen, Yi,Wang, Lu,Liu, Gang,Geng, Meiyu,Zhang, Ao
, p. 2127 - 2142 (2011/06/17)
By use of an improved synthetic strategy, a series of 3,5-disubstituted and 3,5,7-trisubstituted quinolines were readily prepared. 3,5,7-Trisubstituted quinolines 21a-c, 21l, and 27a-c were identified as the most potent c-Met inhibitors with IC50/su
