1268451-38-2Relevant academic research and scientific papers
Rh(III)-catalyzed Directed C-H Olefination using an oxidizing directing group: Mild, efficient, and versatile
Rakshit, Souvik,Grohmann, Christoph,Besset, Tatiana,Glorius, Frank
, p. 2350 - 2353 (2011/05/04)
An efficient Rh(III)-catalyzed oxidative olefination by directed C-H bond activation of N-methoxybenzamides is reported. In this mild, practical, selective, and high-yielding process, the N-O bond acts as an internal oxidant. In addition, simply changing the substituent of the directing/oxidizing group results in the selective formation of valuable tetrahydroisoquinolinone products.
Rhodium-catalyzed oxidative olefination of C-H Bonds in Acetophenones and Benzamides
Patureau, Frederic W.,Besset, Tatiana,Glorius, Frank
supporting information; experimental part, p. 1064 - 1067 (2011/04/16)
A good neighborhood! The metal-catalyzed oxidative C-H functionalization of electron-rich arenes is well-established, but analogous reactions of electron-poor substrates are rare. A new application makes use of common electron-withdrawing functional groups (COMe, CONH2, CONEt 2) in the rhodium-catalyzed oxidative Heck reaction to generate complex organic molecules. Cp= I·5-C5Me 5.
