1268469-14-2Relevant academic research and scientific papers
Signs of formation and chemical evolution of zwitterions in the reaction of 1-methyl-imidazole with cyanophenylacetylene and benzaldehyde
Andriyankova,Belyaeva,Nikitina,Mal'Kina,Vakul'Skaya,Khutsishvili,Sinegovskaya,Trofimov
, p. 1390 - 1394 (2014/07/21)
Primary monitoring of the three-component reaction of 1-methylimidazole with cyanophenylacetylene and benzaldehyde by EPR, UV, NMR, and IR spectroscopy has been carried out. Experimental evidence has been obtained for the formation of zwitterions and carbenes of the imidazole series as intermediates of a new functionalization reaction of the imidazole ring leading to 2-benzoyl-3-(1- methyl-1H-imidazol-2-yl)-3-phenylpropanenitrile.
C(2)-Functionalization of 1-substituted imidazoles with cyanoacetylenes and aromatic or heteroaromatic aldehydes
Trofimov, Boris A.,Andriyankova, Ludmila V.,Belyaeva, Kseniya V.,Mal'Kina, Anastasiya G.,Nikitina, Lina P.,Dyachenko, Oleg A.,Kazheva, Olga N.,Alexandrov, Grigorii G.,Shilov, Gennadii V.,Afonin, Andrei V.,Ushakov, Igor A.
experimental part, p. 1288 - 1293 (2011/04/12)
Substituted imidazoles (substituents are Me, Et, i-Bu, n-Hexyl, (CH 2)2S-Bu-n, Ph, Bn) react smoothly (room temperature, without catalyst and solvent) with cyanoacetylenes (3-phenyl-2-propynenitrile and 4-(1-butoxyethoxy)-4-methyl-2-
