1268514-95-9

Upstream product

• 100-63-0 phenylhydrazine 
• 1698-53-9 4,5-dichloro-1-phenylpyridazin-6-one 
• 496785-25-2 2-phenyl-4-chloro-5-(4-aminophenylthio)pyridazin-3(2H)-one 
• 104-88-1 4-chlorobenzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and antiviral activities of α-aminophosphonate derivatives containing a pyridazine moiety

The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O′-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Copyright Taylor & Francis Group, LLC.