496785-25-2Relevant academic research and scientific papers
Synthesis and antiviral activities of α-aminophosphonate derivatives containing a pyridazine moiety
Zhou, Jun,Fan, Hui-Tao,Song, Bao-An,Jin, Lin-Hong,Bhadury, Pinaki S.,Hu, De-Yu,Yang, Song
, p. 81 - 87 (2011)
The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O′-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Copyright Taylor & Francis Group, LLC.
